All known Mega Drive games
1,223 games from Wikipedia, Wikidata, MobyGames and players' collections. Most are basic entries that list facts from public sources.
Games
- Sailor Moon1993
- Saint Sword1991
- Sampras Tennis 961995
- Samurai Shodown1993
- San San1994
- Sangokushi Retsuden: Ransei no Eiyūtachi1991
- Sangokushi Retsuden: Ransei no Eiyuutachi
- Saturday Night Slam Masters1993
- Scholastic's The Magic School Bus: Space Exploration Game1995
- Scooby-Doo Mystery1995
- Scooby-Doo Mystery1995
- SeaQuest DSV1994
- Second Samurai1993
- Sega Channel
- Sega Classics Arcade Collection1992
- Sega Mega Drive homebrew
- Sega Meganet
- Sega Sports 1 (Europe)
- Sekai Shokubo Sohansen: Kinkangun1994
- Sengoku1991
- Sensible Soccer1992
- Sensible Soccer 20062006
- Sesame Street: Counting Cafe1994
- Sewer Shark1992
- Shadow Blasters1990
- Shadow Dancer: The Secret of Shinobi1990
- Shadow of the Beast1989
- Shadow of the Beast II1990
- Shadow Squadron1995
- Shadowrun1994
- Shanghai II: Dragon's Eye1989
- Shaq Fu1995
- Shi-Kin-Joh1991
- Shi-Kin-Joh1991
- Shikinjoh1991
- Shin Megami Tensei1992
- Shin Megami Tensei II1994
- Shining Force1992
- Shining Force CD1994
- Shining Force II1993
- Shining in the Darkness1991
- Shinobi III: Return of the Ninja Master2008
- Shogi no Hoshi1991
- Shove It! The Warehouse Game1990
- Show do milhão2001
- Show do Milhão Volume 22002
- Shui Hu Feng Yun Zhuan1999
- Shura no Mon1992
- Sid Meier's Pirates!1987
- Side Pocket1986
- Side Pocket1990
- Silpheed1986
- SimEarth1990
- Sink or Swim1993
- Sítio do Picapau Amarelo1997
- Skeleton Krew1995
- Skitchin'1994
- Slam City with Scottie Pippen1994
- Slap Fight1993
- Slap Fight MD1993
- Slaughter Sport1990
- Smash TV1990
- Snake Rattle 'n' Roll1990
- Snow Bros. Nick & Tom2025
- Snow Bros.: Nick and Tom1990
- Socket1993
- Sol-Feace1990
- Sonic & Knuckles2009
- Sonic 3 & Knuckles1994
- Sonic 3D Blast1996
- Sonic Compilation1995
- Sonic Compilation (PAL) / Sonic Classics (NA)
- Sonic Crackers1994
- Sonic Eraser1991
- Sonic the Hedgehog1991
- Sonic the Hedgehog1991
- Sonic the Hedgehog1991
- Sonic the Hedgehog 21992
- Sonic the Hedgehog 21992
- Sonic the Hedgehog 31994
- Sonic the Hedgehog CD1993
- Sonic the Hedgehog Spinball1993
- Sorcerer's Kingdom1993
- Sorcerian1992
- Soulstar1994
- Space Ace1984
- Space Harrier II1988
- Space Invaders: Fukkatsu no Hi1990
- Sparkster: Rocket Knight Adventures 21994
- Speedball 2: Brutal Deluxe2007
- Speedball 2: Brutal Deluxe1990
- Speedball 2: Brutal Deluxe1991
- Spider-Man2000
- Spider-Man / X-Men: Arcade's Revenge1993
- Spider-Man and the X-Men in Arcade's Revenge1993
- Spider-Man and Venom: Maximum Carnage1994
- Spider-Man Animated Series1995
- Spider-Man vs. The Kingpin1990
- Spiritual Warfare1992
- Spiritual Warfare1994
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